Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Microcrystalline Cellulose (MCC) MSDS 1. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Material safety data sheet - FMC Corporation. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. HMo@9, U Q!R/1*;` II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Molecular Weight null. Cellulose microcrystalline. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Well-recognized product that can do it all. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . However, if handling bulk powders, observance of appropriate safeguards is recommended. Delivering efficient and robust formulations. No. Product Name: Microcrystalline Cellulose E460 1.2. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Earth Supplied Products LLC. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. However, it yields non-digestible fibre. In large quantities it provides dietary bulk and may lead to a laxative effect. 51395-75-6 Avicel RC 591. Avicel PH-200 microcrystalline cellulose NF, Ph. . They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. PDF (4.11 mb) Footer menu 1. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. It is . >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[
lH5JWy}DgKRR"Fs By producing Avicel . Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. 2021 Annual Report. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM
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WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Find answers in our support articles. Report Category. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. The typical mean particle size is 20200 m. Catalog Number 102331. 102331. 1 0 obj
Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. CAS #: 9004-34-6 1.6. CAS #: 9004-34-6 . Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. SCMm_>x^O9l (n. "R}~Q:~pgg'"l/O:OV~
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gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. MATERIAL SAFETY DATA SHEET. Your file is uploaded and ready to be published. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. MATERIAL SAFETY DATA SHEET. Validity Area. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C
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g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! All rights reserved. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication 130. Have an order or account question? The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Wu, K. Zuurman, H.W. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. undefined. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. xv}O2' H~KEe9>G/,:9\i iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? 6 0 obj
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The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. The most. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Home. A., and Smith, P. A. %
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Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. These, in turn, are assembled into fibrils in the cell wall. Gloves, eye protection and a dust mask should be used. Microcrystalline Cellulose NF. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. %PDF-1.3 : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Avicel PC 611 (FMC Biopolymer) . : 160182 Date Approved: 05/25/2010 Revision No. Revision No. 2008-2023 ChemPoint. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. cas:9000-11-7 msds Carboxymethyl cellulose. Millipore.
!(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Regulatory Information 2 0 obj
No. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Trademarks: Avicel PH-102. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Instead, they obtained a stable colloidal suspension.