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I hold a Bachelors degree at the University of Toronto where I studied pharmacology. Hutong Cat | China and Russia's invasion of Ukraine: A year later The y axis shows the average of calibrated radiocarbon dates in thousands of years (kyr) (Supplementary Data 1.A). Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. Check out Bootcamps Yes or nah? This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. When expanded it provides a list of search options that will switch the search inputs to match the current selection. Save my name, email, and website in this browser for the next time I comment. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . Genome-wide patterns of selection in 230 ancient Eurasians. Product development is, by far, my favorite data science use case for two main reasons. Los Angeles, California, United States. Otte, M.) 105160 (Errance, 2013). Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The newly defined Fournol cluster is closely related to Aurignacian-associated individuals from Belgium dated to 35ka (Goyet Q116-1 and the newly reported Goyet Q376-3 individual). Ringbauer, H., Novembre, J. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. Designed for aspiring data scientists, data analysts, and BI analysts, this course is the perfect resource for anyone who needs a winning strategy to pass the SQL interview and land their dream job. Details on the allele frequency estimates are provided in Supplementary Information, section12, Supplementary Figs. Sci. Commun. 27 and 28 and Supplementary Data 3.G. In article number 2206752, Hao Zeng and co-workers report a soft actuator assembly capable of windassisted dispersal and lift-off/landing action under the control of a light beam.The design is inspired by the seed of dandelion, resembling several biomimetic features, i.e., high porosity, lightweight, and separated vortex ring generation under a steady wind flow. As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. This suggests that between the Early/Middle and Late Gravettian there was an east-to-west expansion of the Vstonice-associated ancestry that reached central-western Europe and created a longitudinal admixturecline between those two genetically distinct pre-LGM populations. Nature 582, 384388 (2020). 3b). Mathieson, I. et al. The genetic history of Ice Age Europe. PubMed Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. 29, 11691177.e7 (2019). EAGER: efficient ancient genome reconstruction. She graduated with a degree in Computer Science and Applied Math. We use cookies to improve your experience and give you personalized content. You'll likely won't meet her on a day to day basis, but she's always lurking in the Discord and following everybody's progress (not . We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). Natl Acad. Revise SQL essentials, improve your communication style and tackle the most challenging follow-up questions with ease. Chintalapati, M., Patterson, N. & Moorjani, P. The spatiotemporal patterns of major human admixture events during the European Holocene. and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. SQL for Data Science Interviews . Jnsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F. & Orlando, L. MapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Moreover, previous studies have shown that El Mirn carries a genetic contribution from the Villabruna cluster, which is found in Epigravettian-associated individuals from Italy4,15. Jensen, T. Z. T. et al. Reads with a mapping quality below 30 were then filtered with samtools, and the consensus sequences were generated by Schmutzi69. In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com. The long-lasting genetic continuity in Iberia is also reflected in the preservation until the Mesolithic of Y-chromosome haplogroup C, which was predominant in pre-LGM groups but rarely found after the LGM in other parts of Europe (Extended Data Figs. Int. Tina is excellent when it comes to getting overall data science career advice. Ancient genomes indicate population replacement in Early Neolithic Britain. I have an undergraduate degree in pharmacology from the University of Toronto. Fu, Q. et al. 7,794 Followers, 14 Following, 9 Posts - See Instagram photos and videos from Tina Huang (@hellotinah) hellotinah. Alexis Bledel. As a Graduate and Consultant in the Business Tax Advisory (Financial Services) team, I provided tax advice and tax compliance services to organisations in the banking and capital markets, wealth and . Quat. Article H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. Biol. Provided by the Springer Nature SharedIt content-sharing initiative. Jones, E. R. et al. Nucleic Acids Res. The x-axes report the geographic regions as divided in Fig. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a popular YouTuber with over 60K subscribers. Int. Connect with them: Email: hellotinah@gmail.com. TV Actress. Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. Total students. Palma di Cesnola, A. Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). She majored in mathematics before switching to computer science. A.G.-O. After 2 washing steps using the manufacturers wash buffer, DNA was eluted in TET (10mM Tris, 1mM EDTA and 0.05% Tween) in two steps for a final volume of 100l. The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. Evol. All in the name of developing an amazing product! Mathieson, I. et al. In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. The previously described Vstonice cluster, including a newly reported 29,000-year-old individual from Paglicci cave (Paglicci 12) in southern Italy, is closely related to the previously published genomes from Sunghir and Kostenki 12 in western Russia, which are dated to 34ka and 32ka, respectively4,23. As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. We did not correct the calibrated dates for marine or freshwater reservoir effects but, when available, we report individual stable isotope values (15N/13C and C:N ratio) in Supplementary Data 1.A to evaluate the potential impact of such reservoir effects. However, the genetic profile of contemporaneous Gravettian-associated individuals from western Europe remains unknown, as is their contribution to populations after the LGM. Tina Huang is a recent graduate of Stanford. A recent bottleneck of Y chromosome diversity coincides with a global change in culture. 1c) and a west Eurasian principal component analysis (PCA) (Extended Data Fig. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. Notes 9, 88 (2016). This derived ancestrythe Fournol clustersurvived during the LGM in Solutrean-associated individuals, possibly within the Franco-Cantabrian climatic refugium25, leading to later populations associated with the Magdalenian culture (GoyetQ2 cluster and El Mirn). b, Allele frequencies of different hunter-gatherer groups (coloured dots) on four SNPs related to skin colour (SLC24A5 and SLC45A2), eye colour (HERC2/OCA2) and lactase persistence (LCT). On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. Data warehousing is a field where you often have to deal with a lot of raw data. My name is Tina and I'm a data scientist and YouTuber. Natl Acad. The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". AMAZING COURSE! Cosimo Posth, He Yu or Johannes Krause. Tina Huang. Thank you for visiting nature.com. Nucleic Acids Res. 7 and Supplementary Table 3), which coincides roughly with the first appearance of the Oberkassel ancestry in central Europe. Taiwan. Article Rohland, N., Glocke, I., Aximu-Petri, A. 4b and Supplementary Data 3.C). Fourth, we extend the finding of a large-scale genetic turnover as early as 14ka in central and western European hunter-gatherers associated with multiple techno-complexesFedermesser, Azilian and other Final Palaeolithic groups4despite considerable technological continuity with the preceding late Magdalenian. Skoglund, P. et al. If youd like to learn more about data science, transitioning into computer science, and software engineering, you can also subscribe to my YouTube channel. eLife 11, e77625 (2022). Internet Explorer). Bold letters refer to (a) mtDNA and (b) Ychr haplogroups, whose boxes are coloured according to the legend in Extended Data Fig. c, MDS plot of European hunter-gatherers based on 1f3(Mbuti; pop1, pop2). This is one of the things that make us stand out from other platforms which usually consider mathematics and statistics a prerequisite. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. 272273, 354361 (2012). USA 110, 22232227 (2013). Utilized python and R on high performance computing Linux cluster to discover 3 new cancer mutations. Consultant - October 2015 to June 2016. The f4-statistics were calculated by qpDstat 755 with parameter f4 mode: YES, with the Mbuti.DG population from Africa used as outgroup in all f-statistics analyses. 2010, pdb.prot5448 (2010). Genome Biol. The ethane yield of 35.4 mol/h with a high C 2 . Last Name Huang #8. All Rights Reserved. Questions? Interviewed Taiwanese designers and analyzed the interview data. During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. 255, 106796 (2021). Biol. Details of the grouping and ROH segments are provided in Data S3.B. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. Our capabilities include CNC machining, sheet metal Weissensteiner, H. et al. 9; the entire IT and laboratory teams at the Department of Archaeogenetics of MPI-SHH for technical assistance; M. Meyer and S. Nagel for support with single-stranded library preparation; K. Post, P. van Es, J. Glimmerveen, M. Medendorp, M. Sier, S. Dikstra, M. Dikstra, R. van Eerden, D. Duineveld and A. Hoekman for providing access to human specimens from the North Sea (The Netherlands); M. D. Garralda and A. Estalrrich for providing access to human specimens from La Riera (Spain); J. Grski andM. Zajcfor providingaccess tohuman specimensfromMaszycka cave;C. Di Patti for providing access to human specimens from San Teodoro 2 (Italy); P. Blaeviius for providing access to the Donkalnis human remains and the new radiocarbon dates; the Italian Ministry of Culture and Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Verona, Rovigo, and Vicenza for granting access to the human remains of Tagliente 2; F. Fontana, who carries out investigations of the Riparo Tagliente site (Italy); the Friuli Venezia Giulia Superintendency for providing access to the human tooth Pradis 1; and the Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Barletta-Andria-Trani and Foggia for providing access to the Paglicci human remains. Using f4-statistics and qpAdm, we confirm that EHG populations in eastern Europe are a mixture of Villabruna/Oberkassel and ANE ancestries (Supplementary Information, section11 and Supplementary Data 2.K). Besides El Mirn, who has around 43% Villabruna ancestry, all other Magdalenian-associated individuals have a lower proportion of this component (1929%) and can thus be assigned to the GoyetQ2 cluster (Fig. Currently use of the word 'vape' now means "to inhale and exhale the vapor produced by an . Google Scholar. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. Tina Huang | Chemistry at Illinois In a rotator, samples were digested for at least 16h at 37C, and for pre-treated samples this was followed55 by an additional hour at 56C. Genetics 203, 881891 (2016). Front. Srie Prhistoire dEurope 9 (ditions, 2001). The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. Individuals at this site might mark one of the last occurrences of such high levels of hunter-gatherer-related ancestries, just centuries before the emerging European Bronze Age. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). The nuclear DNA contamination was estimated with several methods. We further modelled the genetic profile of pre-LGM individuals with qpGraph (Supplementary Information, section10 and Supplementary Figs. 4 Admixture graph modelling of pre-34 ka hunter-gatherer lineages. There is no biographical data to display. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. Biol. Genomic insights into the origin of farming in the ancient Near East. Dismiss. J. Anthropol. Lipson, M. et al. Notably, the Fournol ancestry provides a better proxy than Goyet Q116-1 for the genetic component found in the GoyetQ2 cluster and in El Mirn (Supplementary Data 2.H). 6, 16581668 (2022). 12). These results show that some, but not all, of the genomic ancestries present in Europe between around 40ka and 30ka survived in the Gravettian-associated populations studied so far. 4a). Evol. Nat. Inconsistent haplogroup assignments were manually verified as indicated24 (Supplementary Data 1.L). Save my name, email, and website in this browser for the next time I comment. The genetic distinction between the Oberkassel and Sidelkino clusters is also clearly noticeable in the diversity of uniparentally inherited markers, as the Oberkassel cluster is dominated by mtDNA haplogroup U5 and Y-chromosome haplogroup I, whereas individuals from the Sidelkino cluster show a higher frequency of mtDNA haplogroups U2, U4 and R1b, and carry uniquely Y-chromosome haplogroups Q, R and J (Extended Data Figs. 2a). Tina Huang - Instructor | 365 Data Science get subscribed to the Brandwatch Bulletin. PubMed Central Yu Ting Wang, Wen Lin Huang, Yan Ting Cheng. Fab Business Solutionsis a ProfessionalNewsPlatform. In each of the past 200 years they have only seen four new entrants into their top 200 list. @hellotinah. van de Loosdrecht, M. et al. Data Engineer Cover Letter Sample and Template. Second, data-driven product development meshes very well with my own philosophy, commonly known as the 80/20 rule, where 80% of the results come from just about 20% of inputs. No, there are no prerequisites for enrolling. Error bars show 1s.e.m. 4. View Tina_Huang_Resume_i.pdf from HCI 445 at DePaul University. ADS This suggests that the newly reported Neolithic individual from central Asia carries an ancestry that might be a good proxy for the ANE-related contribution to Iran and the Turan region45 from around 5.5ka but not to roughly contemporaneous hunter-gatherers from eastern Europe. USA 110, 1575863 (2013). Quat. Here, data really gets to shine, in that its both the source of truth and the driver of insights. The neighbour-joining tree was then reconstructed using the neighbour-joining method implemented in Ape 5.3 package104 of R 3.5.1. For the DNA lysis, a solution of 900l EDTA, 75l H2O and 25l proteinase K was added. The Italian peninsula was previously considered to be another climatic refugium for humans during the LGM. A draft sequence of the Neandertal genome. 5, 820825 (2021). Shes currently at Microsoft. Ancient genomes from present-day France unveil 7,000 years of its demographic history. 12 Data Science YouTube Channels by Women to Follow Cardiff University / Prifysgol Caerdydd. To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. 46, 6584 (2020). Rivollat, M. et al. R. Soc. My experience includes an internship at Goldman Sachs where I did some machine learning work before I took up my current data science job in tech. This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). Quat. Huang, Y. Ice Age survivors. We show that all analysed Epigravettian-associated individuals carry a homogeneous Villabruna ancestry, with the intra-group genetic structure mainly determined by their geographical, and not temporal, distribution. Extended Data Fig. The genomic history of the Iberian Peninsula over the past 8,000 years. 15, 193223 (2005). Synergy of Ag and AgBr in a Pressurized Flow Reactor for Selective We only plotted groups with more than two individuals and, for this reason, individuals from the GoyetQ116-1 cluster are included here into the Fournol cluster. 3,528. Tina Huang. We used the default posterior threshold of 0.01, and mapping and sequencing quality cutoffs of 30. Saag, L. et al.