Meanwhile, the Department of Justice is investigating myocarditis (inflammation of the heart) following cases in vaccinated service members. The information is still valuable because its a way of being quickly alerted to a potential safety issue with a vaccine, which can then be followed-up by government scientists. Much mrna will be destroyed fast by enzymes but some will trigger the cell to produce the spike proteins. What the researchers found was a bit of a surprise: the vast majority of antibodiesabout 84 percenttargeted other portions of the spike protein than the RBD. See: https://www.jpost.com/health-science/could-an-mrna-vaccine-be-dangerous-in-the-long-term-649253, If these spike proteins are expressed in endothelial cells, which are found in the vascular system, brain and other organs, the protein can presumably damage that tissue in a way that may not be readily apparent. There is some evidence that the spike proteins generated by the Moderna Covid-19 vaccine leave the site of injection. Even if its turns out to be true that mRna spike proteins can harm your cells. These proteins combine to form the telltale spikes on the SARS-CoV-2 virus. That if one drink from it ! Whats more, we have Dr. Fauci and others President Biden among them too insisting that the fully vaccinated continue to wear their masks. DOI: 10.1016/j.isci.2023. If a burgler, theoretically, is born inside your house and cannot get out alive and is killed by the residents, there is no damage and no damage in the future at other houses. With nRNA vaccine technology the spike protein is made inside the cellular machinery, but it goes on to be destroyed once it is made inside the cells and CAN NOT EXIT the Cell intact. . Press release, Government of Canada, Health Canada. 1 ENTERING A CELL 1 Entering a Cell Now, when the cell gets destroyed, all spike proteins which were produced shortly and did not become destroyed yet will float through your tissue and if you are unlucky, enter a blood vessel. https://youtu.be/t9VObXY8szchttps://clinicaltrials.gov/ct2/show/NCT04311697, Aviptadil is now in internatial research project with Remdesivir, which could help in start of the sickness.https://www.nih.gov/news-events/news-releases/clinical-trial-therapeutics-severely-ill-hospitalized-covid-19-patients-begins. take a few minutes. Any cell they successfully enter will then make trillions of the vaccine induced synthetic (made on an altered computer model of the protein) spike protein. Would these vaccines not cause similar harm? 5 May 2021. Vaccines that trigger spike protein production only affect a very limited number of cells, as the genetic material that these vaccines contain does not auto-replicate in the body. > Subscribe Free to Email Digest, UCLA astronomers think the object, X7, might be debris cloud from a stellar collision. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. 21 May 2021. 01 In severe COVID-19 cases, immune cells in the infected windpipe and lungs can release high levels of damaging Because COVID-19 affects so many bodily systems, Panda is studying gene activity in COVID patients to see how day-to-day changes in this activity and the clinical symptoms of COVID predict treatment outcomes. But since its not part of a virus, it cannot replicate. That could explain why some people have strokes, and why some people have issues in other parts of the body. Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. It must first be understood by all. e unevidenced. I imagine the commenter who thought that spike making cells destroyed would release unnattached spike protein into the body was correct. 20 May 2021. DOI: Severe adverse reactions to the vaccines have been rare. COVID-19 Vaccine-Generated Spike Protein is Safe, Contrary to Viral In reality, Covid-19 is BOTH a vascular and a respiratory disease. Two of the earliest vaccines approved in the US were delivered by Moderna and Pfizer-BioNTech. The new technology treatments give mRNA to teach your own cells to make the spike proteins. Why did he or she do it ? levels in the lungs alter the course of the disease. University of Guelph. Eckhart, professor emeritus and director of the Salk Institute's National Cancer Institute-designated Cancer Center and head of the Molecular and Cell Biology Laboratory for more than 30 years, died on June 21, 2022, at his home in La Jolla, California, at the age of 84. . Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others. Furthermore if vaccine induced spike were pathogenic wouldnt we see a lot of illness following vaccination?, Finally, Bridle says there is evidence that the mRNA vaccines get transferred through breast milk, citing apreprint from Singapore that tested milk samples from 10 lactating health care workers after they were immunized with the Pfizer/BioNTech vaccine. Incredible this document is even published. Centers for Disease Control and Prevention. Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own. Bridle is taking our results and completely misinterpreting them, said David R. Walt, a member of the faculty at Harvard Medical School and of Harvards Wyss Institute for Biologically Inspired Engineering, who co-authored a study that found circulating SARS-CoV-2 vaccine antigen in the plasma of vaccine recipients. We discuss the paper, the authors' clarification. the spike protein induced by the vaccine are made in the cell if they stayed in cell or were destroyed there = no antibodies would be made. (a pretty tall order) There is not enough of the viral matter in the vaccine to do significant harm without replication, which it cannot do. Bryam Bridle profile. All of the COVID-19 vaccines currently approved in the United States are designed to instruct human cells to make harmless spike proteins mimicking a viral protein that's used by the. He has designed this test, which will Interview, Dr. Paul Offit, director of the Vaccine Education Center and an . The novel coronavirus' spike protein plays additional key role in illness Save my name, email, and website in this browser for the next time I comment. Founder and currently Executive Editor of Science-Based Medicine Steven Novella, MD is an academic clinical neurologist at the Yale University School of Medicine. According to a statement sent to FactCheck.org by the National Institute of Allergy and Infectious Diseases, the vaccine-generated spike protein is not secreted into circulation in the bloodstream.. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. Covid 19 Vaccine Requirement to Transfer through Frankfurt And so theres no risk of transmission through the breast milk. Those who point out that the vaccine spike proteins can enter the bloodstream are correct. Theunpublished study found antibodies in the breast milk from all of the workers andminimal amounts of vaccine mRNA.. The authors believe that this is good news with regard to the vaccines currently in circulation; they may be right. No.I also got a history of rare autoimmune disease involving the blood vessels.The question is, do these spike proteins stay in the cells long enough to produce any damage ? It is locked in the pre-fusion state to stabilize it not to prevent binding. A study out of Israel implies that prepping the immune system to expect the original COVID-19 may paradoxically put it at a disadvantage when exposed to the South African variant. 128, No. Since the pandemic started, his lab has been trying to develop vaccines against coronaviruses, for which he received a $230,000 grant from the Ontario government. , a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for. SciCheck Digest. Alan Saghatelian and Joseph Noel are exploiting the atomic Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.Science. In order to overcome the viruses. Most use a recombinant spike glycoprotein: either mRNA based (the Moderna and Pfizer-BioNTech vaccines), via an adenovirus vector (the Oxford-AstraZeneca, CanSino, and Johnson & Johnson vaccines), or via injection of the protein itself (the Novavax vaccine). The study, in which researchers administered a pseudovirus to hamsters, found the spike protein alone can damage vascular endothelial cells. But as the authors mention, the use of a pseudovirus is a limitation and findings need to be confirmed with the SARS-CoV-2 virus in the future. . 17 June 2021. 02 Creating a protective coronavirus vaccine is SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. Fact Check-COVID-19 vaccines are not 'cytotoxic' | Reuters COVID-19 Vaccines: Myth Versus Fact | Johns Hopkins Medicine The one Dr. Malone particularly pushed is from Salk Institute, where researchers injected SARS-CoV-2 spike proteins into hamsters, which injured the lungs and blood vessels due to angiotensin . Until he approached it and looking down saw down into the earth and was alarmed. Spikes created inside cells from mRNA are degraded before they exit the cell through the MCH mechanism and the result it the standard immune system hand off is made to fully consume and degrade these protein peptides. This frees the (likely many) whole and partial spike proteins inside the cell into the blood. The spike protein, particularly the RBD, is therefore the main antigenic target for vaccine formulation. Walt told us in an email that the aim of the study was to see if an ultrasensitive detection technology, a single-molecule array, could detect circulating antigen produced by the mRNA vaccine to demonstrate the vaccine is working as designed. Science. Vaccines, pregnancy, menstruation, lactation and fertility. Spikes and spike protein fragments move to the outside of the cell and protrude from the surface where they will be recognized by the immune system. Simply put, there are too many VAERS adverse event reports to pass off all serious aftereffects as coincidence or to dismiss them as background rates. (Salk Institute) Usually, a person's immune system turns on when it's needed, slays an infection, then turns off. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal modelproving that the spike protein alone was enough to cause disease. All of the COVID-19 vaccines currently approved in the United States are designed to instruct human cells to make harmless spike proteins mimicking a viral protein thats used by the SARS-CoV-2 virus to enter cells. Ghazvini, Keanna. 02 Gerald Pao, a staff scientist in the Hunter lab, will work Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.. Accessed 29 June 2021. https://www.euronews.com/2021/06/02/pfizer-covid-19-vaccine-linked-to-myocarditis-in-young-men-says-israel-s-health-ministry, Heart inflammation from Vaccine discovered . 2. your beta cells then process and read the enzyme with the mrna of the spike to watch out for the foot that will cause all this damage. But recent studies in animals and cultured cells have found . The highest concentration of BNT162b2 mRNA in the tested samples was 2 ng/mL a hypothetical 0.667% of the original vaccine dose being transferred in 100 mL of human milk, the study says. Spike protein in COVID vaccines is not cytotoxic | 11alive.com The majority of people wouldnt even know they had covid. My educated guess is this: Now that the vaccines are about to be used in kids as young as 12, I expect a more robust immune response and the presence of a better (faster) metabolism will translate into more immediate reports of adverse events among younger vaccine recipients the same group (with some exceptions!) This is cellular biology 101. In the case of the COVID-19 vaccines, randomized controlled trials involving tens of thousands of people, which were reviewed by multiple groups of experts, revealed no serious safety issues and showed that the benefits outweigh the risks. This means that very large amounts of circulating spike proteins are produced, generating the adverse effects that the authors identified in their study. Im a layman but I think I got it.The damage happens when a free spike protein binds to a cell. This "teaches" the body's immune system to fight the virus that has that specific spike . But the devil and his seed cannot go into it !!!! There is no evidence that the spike protein in vaccines is toxic or that it lingers at any toxic level in the body after vaccination, an FDA spokesperson told us in an email. Accessed 29 June 2021. As the old saying goes, where there is smoke there is fire. Copyright 2023 Salk Institute for Biological Studies, The novel coronavirus spike protein plays additional key role in illness. SARS-CoV-2's distinctive "spike" protein plays a key role in the disease itself, shows study Download PDF Copy Reviewed by Emily Henderson, B.Sc. Spikes and spike protein fragments move to the outside of the cell and protrude from the surface where they will be recognized by the immune system. We thought the spike protein was a great target antigen, we never knew the spike protein itself was a toxin and was a pathogenic protein. 17 June 2021. THUS VIRUSES WERE CREATED WITH CERTAIN INTELLIGENCE IN THE PHYSICAL ENVIRONMENT. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. Read more here. SARS-CoV-2 spike protein induces abnormal inflammatory blood clots Reuters Fact Check . The commonality between them is that they all have vascular underpinnings.. 8 June 2021. Both the American College of Obstetricians and Gynecologists and the World Health Organization encourage women who are breastfeeding to take the vaccine. asking for a concerned friend who took the vaccine. WHAT WE FOUND "The bottom line is the vaccine spike. COVID-19 patients to determine if a drop in surfactants is MAN WAS CREATED BY GREAT INTELLIGENCE. This article is a reprint of what I assume is the original source here: https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/. synthetic virology and chemical biology platforms, to create 5 May 2021. Pine Needle Tea: The Best Potential Antidote for Transmission of Spike It is incredibly safe., A second study Bridle uses to support his claims is one by Pfizer. The mRNA vaccines builds the protein within the safe environment of the host cell structure from the inside outspikes are not created outside this environment. While previously working on a vaccine for MERS, a disease caused by another coronavirus, McLellan and others, that by adding two proline molecules to the spike protein, they could lock it into its pre-fusion state, triggering a more effective immune response and preventing cell entry. Anyone can submit a report of an event to VAERS, even if its not clear that a vaccine caused the problem, and all of the notifications are accepted without determining if the event was caused by a vaccine. 4 June 2021. development of COVID-19. Covid's spike protein plays key role in illness: Study Email sent to FactCheck.org. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal modelproving that the spike protein alone was enough to cause disease. Some one in the scientific community must comment on the joint sites of cooperationof the research and the varied nationality of the scientists working on the project! COVID vaccines and breastfeeding: what the data say, American College of Obstetricians and Gynecologists. Walt, David. They showed that the spike protein damaged the cells by binding ACE2. on SARS-CoV-2 antibodies in breast milk following vaccination, told us there is no evidence to support Bridles claims. The study's last sentence says that when someone receives a. Why cant people sue pharmaceutical companies if they have disabling reactions or their family members die from it? There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. I think, adverse effects of the vaccine happen more often if the needle hits near a bigger blood vessel in the muscle. Even if the spike protein was absorbed into the blood stream, it has no mechanism of action to cause any issues such as bleeding disorders., According to the CDCs website there is limited data available on the safety and the effects of vaccination in lactating people or breastfed babies because the clinical trials didnt include people who were breastfeeding. 31 Mar 2021. COVID-19 Vaccination Considerations for ObstetricGynecologic Care. Updated 9 June 2021. When either Sars-CoV-2 or HIV infects a person both viruses only cause an innocuous flu-like infection but like HIV, the Sars-CoV-2 spike protein can linger in the body attacking the T cells of the immune system. See: https://www.npr.org/2021/02/09/965703047/vaccines-could-drive-the-evolution-of-more-covid-19-mutants. The, , called 2P, as in two proline molecules, is, No Evidence Vaccine-Generated Spike Protein Is Harmful, prepared in response to the attention brought by the interview, Bridle says the Canadian government should be called upon to immediately halt the mass vaccination program of children and adolescents. He says there is no immediate threat of severe COVID-19 in the majority of Canadian children and adolescents, and that more safety and efficacy data is needed for the use of experimental vaccines., the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. Manor labs and Ogata's study confirm. Retweeted. genetics, immunology, plant biology and more. The miscegenation seems to be the common factor for the number of new variants from South Africa, Brazil, United Kingdom and the United States. Show replies. There is no damage when the spike protein is just inside a cell. Bridle presents the study as evidence that the spike protein gets into blood circulation. What leads you to believe that the spike protein will remain in the cell vs. expressed into the surrounding tissue by which not only antibody response will be built up (a good thing) but also attack by NK cells (another aspect of the immune system) and thus pro-thrombotic, pro-inflammatory aftereffects? It is not true that spike proteins cant exit cells, because reactions in your cells do not happen immediately. Updated 21 June 2021. over our editorial decisions, and the views expressed in our articles do not necessarily reflect the views of the foundation. a San Diego biotechnology company to develop COVID-19 . Ontario Veterinary College website. Structural biologist at the University of Texas at Austin. Surfactant is a substance Continue with Recommended Cookies, Representative images of vascular endothelial control cells (left) and cells treated with the SARS-CoV-2 Spike protein (right) show that the spike protein causes increased mitochondrial fragmentation in vascular cells. According to the NIAID statement, the spike protein is only detectable for a few days after immunization in tests conducted in animals. By: Express News Service The spike protein encoded by the mRNA vaccines (Moderna and Pfizer/BioNTech) and the J&J vaccine instruct the cells in our arm (where the injection is given) to produce spike protein that is tethered to the surface of the cell. Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies 2. Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.. For proof, see for instance https://www.aljazeera.com/news/2021/5/3/india-covid-cases-near-20-million-uk-to-send-more-aid-live-news. And he thought it was glass laying down on the ground. mimics the ones on the coronavirus. Research Institute, will examine the role of memory T cells Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xian, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. But does that hold true for the rest of us? An overview of spike protein antigen COVID-19 vaccine candidates Pfizers vaccine pharmacokinetics overview. Or more exactly between Russia,China, and the Eastern Province of Tibet. When the immune system recognizes the proteins, which arent normally there, it starts generating antibodies and building an immune response against them. [T]he spike protein from SARS-CoV-2 might be responsible for at least some of the damage that occurs in severe cases of COVID-19, he says, citing a study published in March in Circulation Research. D New research: Besides initiating infection, coronavirus spike protein Accessed 29 June 2021. The commonality between them is that they all have vascular underpinnings.. To view the purposes they believe they have legitimate interest for, or to object to this data processing use the vendor list link below. The spike also activates CD4 and CD8 T cells from anywhere beyond 70% of COVID-19 patients . But the system sometimes attacks a person after a virus is no longer a threat. . Updated 29 June 2021. We made a big mistake, said Byram Bridle, a viral immunologist and associate professor at the University of Guelphs Ontario Veterinary College, during an interview with Canadian radio personality Alex Pierson on May 27. Our conclusion was that the vaccine is working as intended.. Based on this outline, we have reviewed the structure . We found we could detect extremely low concentrations of S1 (a subunit of spike) in 11 of 13 healthy vaccinated individuals and the full spike in 3 of 13, he said in an email, noting that the technology they used is 1,000 times more sensitive than a typical antigen test, so we are really detecting minute quantities of the spike and S1 proteins. (Emphasis is his). COVID-19 spike protein damages blood vessels The "spike" proteins that the coronavirus uses to help it break into cells inflicts other damage as well, according to a new study that shines a. Walt, a pathology professor, added there is no evidence that the spike protein is a pathogenic protein that causes damage in several tissues. Accessed 29 June 2021. No vaccine is perfectly safe. It is a calculated risk. Experts say the spike protein created by the human body after mRNA vaccination is different than the SARS-CoV-2 spike protein. The researchers will use Jason McLellan, a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for years and whose work was fundamental for the development of COVID-19 vaccines, said Bridles statements are not correct. The novel coronavirus spike protein plays additional key role in illness. More confirmation watch this: https://youtu.be/9EfToFXwx98?t=479. Accessed 29 June 2021. This conclusion suggests that vaccination-generated antibody and/or exogenous antibody against S protein not only protects the host from SARS-CoV-2 infectivity but also inhibits S protein-imposed endothelial injury. So clean,white,and pure. And white !!!! An explosive new study by researchers at the prestigious Salk Institute casts doubt on the current crop of gene-based vaccines that may pose a grave risk to public health. document.getElementById("ak_js_1").setAttribute("value",(new Date()).getTime()); SciTechDaily: Home of the best science and technology news since 1998.